Congratulations to Dr. Weihong Song on receiving CIHR Operating Grant

Dr. Weihong Song has been awarded a 5-year, $994,500 CIHR operating grant for his research project “The effect of a novel presenilin 1 mutatio non Alzheimer’s Disease pathogenesis”. The project will seeks to investigate how this PS1 mutation selectively regulates APP without affecting Notch cleavage, and to define the mechanism underlying the PS1’s role in AD pathogenesis. The study highlights a possibility of developing novel specific gamma-secretase modulators as drugs that inhibit Abeta generation but may maintain normal Notch signaling for AD treatment.