Congratulations to Dr. Lynn Raymond on being awarded a major CIHR project grant in the Spring 2021 competition!
As the principal investigator on this 5-year funded project titled “Role of altered endoplasmic reticulum calcium regulation and the N-methyl-D-aspartate (NMDA) receptor signaling in cortico-striatal synaptic dysfunction: Opportunities for therapy in prodromal Huntington disease,” Dr. Raymond and her team will focus on two major mechanisms, the cellular calcium storage and release compartment called the endoplasmic reticulum, and the NMDA receptor, a protein complex that receives and transmits signals by the brain chemical glutamate, in order to investigate underlying changes in synapses between the cortex and striatum at the onset of Huntington Disease (HD). Her study will address a critical need to develop complementary therapies to normalize function of brain connections before clinical disease begins and maintain normal function longer in HD gene mutation carriers.
Congratulations to Dr. Raymond on receiving this significant funding!
Read more detailed information about this project on the CIHR Funding Decisions page.