Jeremy Seamans

Jeremy Seamans

Jeremy Seamans

Professor, UBC Department of Psychiatry, Division of Neuroscience and Translational Psychiatry

Member, Djavad Mowafaghian Centre for Brain Health

Email: jeremy.seamans@ubc.ca

Short Biography

Dr. Jeremy Seamans is Professor of Psychiatry. His lab uses powerful optically-based tools (e.g. optogenetics and fluorescence imaging) to examine the function of the Anterior Cingulate Cortex (ACC), and its modulation by neurotransmitters, using recordings from animals performing cognitive or emotional tasks.

Research Focus

Dr. Seamans’ main research interest lies in a part of the brain known as the Anterior Cingulate Cortex (ACC). There is no consensus on what the ACC actually does, although there are no shortage of theories. On one hand, functional imaging has shown that the ACC is “activated” during a staggering array of cognitive and emotional tasks. On the other hand, when the ACC is surgically removed (anterior cingulotomies) in human patients for the treatment of severe cases of obsessive compulsive disorder, chronic pain or depression, no lasting detrimental effects on cognition, memory or emotional expression occur.

Dr. Seamans’ lab takes a reductionistic approach to understanding this mysterious brain region. This involves simultaneously recording from many ACC neurons as animals perform various cognitive or emotional tasks. They then apply sophisticated statistical and machine learning techniques to extract meaningful signals from the jumble of activity. Typically, the team finds that ACC neurons can represent almost anything (e.g. stimuli, actions, outcomes and emotional states) but perhaps more interesting is that these representations morph or change with changes in context. Because we believe the morphing relies on neuromodulators such as dopamine and serotonin, Dr. Seamans uses powerful optically-based tools (e.g. optogenetics and fluorescence imaging) to tract fluctuations in these modulators.

By studying how ACC neurons represent cognitive and emotional information and what causes these representations to change, Dr. Seamans’ lab hopes to better understand what the ACC normally does, and how dysfunction of the ACC might contribute to severe psychiatric disorders.

Significant Accomplishments & Professional Contribution

2015 UBC Faculty of Medicine Distinguished Achievement Award – Excellence in Basic Science Research

Peter B. Reiner

Lynn Raymond

Lynn Raymond

Professor & Louise A. Brown Chair in Neuroscience, UBC Department of Psychiatry, Division of Neuroscience and Translational Psychiatry

Director, Djavad Mowafaghian Centre for Brain Health

Director, Huntington Disease Medical Clinic

Researcher, Vancouver Coastal Health Research Institute

Associate Member, Division of Neurology (Medicine) & Department of Cellular and Physiological Sciences

Email: lynn.raymond@ubc.ca

Short Biography

Dr. Lynn Raymond is the Director of the Djavad Mowafaghian Centre for Brain Health. She is also a Professor in the Department of Psychiatry, the Louise A. Brown Chair in Neuroscience and Clinic Director of the Centre for Huntington Disease.

Dr. Raymond is an internationally renowned neuroscientist and neurologist, and her work bridges foundational science and clinical research. She has more than 170 publications, and her work has been cited more than 11,000 times. She has devoted her career to better understanding the specific roles of altered neuronal circuits and amino acid neurotransmitter receptors in Huntington disease, with the aim of developing disease-modifying therapy. Her work is funded by the Canadian Institutes of Health Research, the John Evans Leadership Fund, and she has held funding from a variety of not-for-profit organizations including the Cure Huntington’s Disease Initiative and Huntington Society of Canada.

Research Focus

Dr. Lynn Raymond combines neuroscience research with clinical practice in Neurology. Her lab investigates pathogenic mechanisms of Huntington disease (HD), as well as glutamate receptor structure-function, modulation and signaling. Working with HD mouse models, Dr. Raymond made significant contributions to focusing the field on altered striatal neuronal NMDA-type glutamate receptor (NMDAR) trafficking and excitatory synaptic signaling as central mechanisms of early striatal dysfunction. More recently, her lab has focused on early changes in cortical-striatal and cortical pyramidal glutamatergic synaptic plasticity, which may contribute to impairments in learning and cognitive flexibility, as well as promote selective neuronal degeneration. The lab also developed an automated home-cage system for assessing motor learning, and uses electrophysiological and optogenetic approaches to study cortical and striatal activity in awake behaving mice in vivo to determine circuit changes underlying HD. Dr. Raymond served as President for the Canadian Association for Neuroscience. As Site PI of several clinical trials and observational studies, she contributes data to publications on multi-centre studies in HD

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Anthony Phillips

Anthony Phillips

Professor, UBC Department of Psychiatry, Division of Neuroscience and Translational Psychiatry

Scientific Director, Mental Health and Addiction, CIHR Institute of Neurosciences

Founding Director, UBC Institute of Mental Health

Senior Scientist, UBC/VCH Brain Research Centre

Member, Djavad Mowafaghian Centre for Brain Health

Researcher, Vancouver Coastal Health Research Institute

Email: anthony.phillips@ubc.ca

Short Biography

Dr. Anthony Phillips received his PhD in Psychology from the University of Western Ontario, under the mentorship of Gordon Mogenson and subsequently spent time in the laboratories of Elliot Valenstein and James Olds at the Fels Research Institute and Division of Biology at the California Institute of Technology, respectively.

He joined the Department of Psychology at the University of British Columbia in 1970, was appointed full professor in 1980. He then served as head of the department from 1994-99. He subsequently joined the Department of Psychiatry, Faculty of Medicine, UBC in 2000 and became the Founding Director of the UBC Institute of Mental Health in 2005. Dr. Phillips served for two terms (2001-07) as the inaugural Chair of the Advisory Board for the CIHR Institute of Neurosciences, Mental Health and Addiction.
Dr. Phillips also played an important role in the evolution of the biotechnology industry in Canada, having been a Founding Director of QLT and serving as Secretary/Treasurer to its Board from 1982-92, and currently as a Founder and Member of the Board of Allon Therapeutics Inc. He has been elected as President (2012-14) of the Collegium Internationale Neuro-Psychopharmacologicum (CINP).

Research Focus

Dr. Phillips’ research interests are broadly based within the field of pre-clinical neuropsychopharmacology and systems neuroscience. He has published over 300 peer- reviewed articles and book chapters. His pioneering research, with H.C. Fibiger, laid the foundation for the role of dopamine in the neural control of motivation and memory, with its clinical implications for understanding biological correlates of addiction. He has a long-standing interest in applying knowledge concerning normal brain-behavior function to understanding the neural bases of mental illness and addiction.

Significant Accomplishments & Professional Contribution

Dr. Phillips’ distinguished awards include: Canada Council Killam Senior Research Scholar (1978-80) and E.W.R. Steacie Fellow, NSERC (1980-82). In 1986, he was elected a Fellow of the Royal Society of Canada and was also the recipient of an inaugural UBC Killam Research Prize. The Canadian Psychological Association honoured him in 1995 with the Donald O. Hebb Award for `Distinguished Contributions to Psychology as a Science.’ In 1996, the Canadian College of Neuropsychopharmacology awarded him with the inaugural prize for `Innovations in Neuropsychopharmacoloty’ (with H.C. Fibiger) and in 2009, with the Heinz Lehmann Award. In 2010, Dr. Phillips was elected a Fellow in the Canadian Academy of Health Sciences.

Paul Pavlidis

Paul Pavlidis

Professor, UBC Department of Psychiatry, Division of Neuroscience and Translational Psychiatry

Associate Director, UBC Graduate Program in Bioinformatics

Member, Djavad Mowafaghian Centre for Brain Health

Email: paul@msl.ubc.ca

Short Biography

Dr. Paul Pavlidis is a Professor of Psychiatry based at the Michael Smith Laboratories. He obtained his B.A. in Biochemistry from Cornell University (1989) and his doctorate in Molecular Biology/Neursocence from the University of California, Berkeley (1994). He completed post-doctoral fellowships at Stanford University and Columbia University prior to his appointment as Assistant Professor at Columbia University in 2003. He moved to UBC in 2006 and was promoted to full professor in 2014. His lab focuses on research that is at the intersection of bioinformatics and neuroscience, with a focus on genomics.

Research Focus

Dr. Pavlidis’ research lies at the intersection of bioinformatics and neuroscience. Dr. Pavlidis has a particular interest in neuropsychiatric disorders such as schizophrenia and autism, and how they affect the function of chemical synapses. A current focus of work in his lab involves the large-scale or meta-analysis of functional genomics data (e.g. microarrays). He uses these approaches to study gene networks and their involvement in human neuropsychiatric diseases. To this end Dr. Pavlidis collaborates closely with many laboratory-based neuroscience researchers from UBC and elsewhere. A newer area of interest is in the analysis of neuroanatomical data. Using text mining as well as existing data sources, he is engaged in the analysis of brain structure as it relates to gene expression and the brain “connectome”. As computational biologists, they also generate methods, databases and tools. One of the tools they have developed, “Gemma” is a system that permits researchers to compare and combine gene expression data sets they have generated with other data sets they select from hundreds of other data sets. Gemma will also facilitate the use of other types of data including and proteomics and genetics, and neuroscience-domain-specific data such as neuroanatomy and neuropharmacology.

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William Panenka

William Panenka

Associate Professor, UBC Department of Psychiatry, Division of Adult Psychiatry and Mental Health Services

Associate Program Director, Research Track, UBC Department of Psychiatry, Postgraduate Residency Program

Medical Lead, Neuropsychiatry Concussion Clinic

Neurology Consultant, Fraser Health Acquired Brain Injury Concussion Clinic

Investigator, BC Children’s Hospital Research Institute

Researcher, BC Mental Health and Substance Use Services Research Institute

Researcher, Vancouver Coastal Health Research Institute

Member, Djavad Mowafaghian Centre for Brain Health

Email: will.panenka@ubc.ca

Short Biography

Dr. Panenka is a dually certified psychiatrist and neurologist and assistant professor in the department of psychiatry at UBC. He is the research lead of the BC Provincial Neuropsychiatry program and a researcher with the BC Mental Health and Substance Use Services Institute and the Djavad Mowafaghian Centre for Brain Health. He is the medical lead at the Neuropsychiatry Concussion Clinic and Neurology consultant to the Fraser health concussion clinic.

Dr. Panenka’s laboratory has been very productive thanks to a number of excellent graduate students and fellows. The laboratory encourages career growth along any trajectory and has been successful in placing learners into academia, medicine, industry and a number of allied health disciplines. We welcome applications year round from dedicated, self-motivated, and personable candidates.
Degrees / Credentials: MD, MSc, FRCPC (Neurology and Psychiatry)

Research Focus

As a clinical researcher my main goals over the next five years are to continue my work with the homelessness in Vancouver’s downtown east side, and set up a mild traumatic brain injury research program at the University of British Columbia.

Vancouver’s downtown east side is home to our most vulnerable population, characterized by a mixture of primary psychiatric illness and refractory addictions. As part of a large team led by Dr. Bill Honer (Head of Psychiatry) we recruit individuals housed in single room occupancy hotels who then undergo detailed medical and psychiatric testing, including brain MRI. This is a longitudinal study that follows approximately 500 individuals for up to 5 years. The data generated is important to policy makers and to science. There are a multitude of opportunities to explore psychiatric and neurological illness from many angels within this study.

My lab is concurrently engaged in the study of traumatic brain injury. We are building a strong team that includes multiple researchers from multiple disciplines here at UBC and abroad. Under the umbrella of the BC Neuropsychiatry program we have recently started the “Neuropsychiatry Concussion Clinic” for those individuals with symptoms that do are not resolving following head trauma. This clinic and others serve as recruitment sites for research studies that focus on the development of bio-markers in concussion, which simply put means finding cognitive, imaging, and blood markers that may predict outcome and response to treatment in those with brain injuries.

John Ogrodniczuk

John Ogrodniczuk

Professor, UBC Department of Psychiatry, Division of Adult Psychiatry and Mental Health Services

Founder, HeadsUpGuys

Past-President, North American Chapter of the Society for Psychotherapy Research

Founder, Optimum Life Consulting

Director, UBC Psychotherapy Program

Email: john.ogrodniczuk@ubc.ca

Short Biography

Dr. John Ogrodniczuk is a Professor of Psychiatry and Director of the UBC Psychotherapy Program, one of North America’s largest medically based psychotherapy training programs.  His research program focuses on a variety of psychotherapies and patient populations, with a particular focus on personality disorders and men’s mental health. Dr. Ogrodniczuk has held several grants to support his research, which has led to over 300 scientific publications.

In addition to his research, Dr. Ogrodniczuk is involved with teaching medical students and psychiatry residents, serves as a mental health consultant for various organizations, and maintains a psychotherapy practice. Dr. Ogrodniczuk is the Founder of HeadsUpGuys, a leading global resource for supporting men with depression.

Research Focus

Psychodynamic Psychotherapy, Personality Disorders, Men’s Mental Health, Alexithymia, Workplace Mental Health

Significant Accomplishments & Professional Contribution

Outstanding Early Career Achievement Award, Society for Psychotherapy Research

Past-President, North American Chapter, Society for Psychotherapy Research

Distinguished Research Career Award, Society for Psychotherapy Research

Champion of Mental Health Award, Canadian Alliance on Mental Illness and Mental Health

Tonia Nicholls

Tonia Nicholls

Professor (Partner), UBC Department of Psychiatry, Division of Forensic Psychiatry

Adjunct Faculty, Department of Psychology, SFU

Researcher, BC Mental Health and Substance Use Services Research (BCMHSUS) Institute

Distinguished Scientist, Forensic Psychiatric Services Commission, BCMHSUS

Investigator, BC Children’s Hospital Research Institute

Email: tnicholls@phsa.ca

Short Biography

Dr. Nicholls is Professor, Department of Psychiatry, UBC and Distinguished Scientist at the Forensic Psychiatric Services Commission, BCMHSUS. She holds cross-appointments at UBC including the SPPH and an Adjunct appointment in the Department of Psychology, SFU.

Her research examines the intersections of law and mental health related to the provision of services to persons in conflict with the law and diverse marginalized populations focusing on assessment and treatment of violence, criminality and the development and implementation of EBP. She has published manuals to support the translation of research into practice and has engaged in large-scale implementations and evaluations; these include violence risk assessments and mental health screening in correctional settings, mental health assessments and treatment planning (see manuals).

Her scholarly work has earned her and her teams multiple grants and awards totalling over $15 million. Recently she received a CIHR Foundation award (> $2 million; 2015-2022) to fund her research.

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Research Focus

Topics at the intersections of law and mental health. Including risk assessment and management (suicide, violence, self-harm); measure development and psychometrics; mentally ill individuals who come into conflict with the law; psychopathy; domestic violence; resiliency, recovery, victimization and homelessness; de-institutionalization and trans-institutionalization.

Significant Accomplishments & Professional Contribution

2017 Significant Contribution Award, Canadian Psychological Association, Criminal Justice Section

2016  Canadian Institutes of Health Research -Foundation Award

2016  New Zealand Chad Buckle Visiting Fellowship, Mental Health, Addictions, & Intellectual Disability Directorate, Wellington, NZ 

2012 Quality Award – Short-Term Assessment of Risk and Treatability Program, BC Patient Safety & Quality Council

2011  Accreditation Canada Leading Practice – Short-Term Assessment of Risk and Treatability  

2004  President’s New Researcher Award, Canadian Psychological Association 2004  Distinguished Professional Contribution, American Psychological Association/APAGS

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Elton Ngan

Elton Ngan

Associate Professor, UBC Department of Psychiatry, Division of Neuroscience and Translational Psychiatry

Researcher, Vancouver Coastal Health Research Institute

Educational Case Rounds Co-ordinator, Department of Psychiatry, Lions Gate Hospital

Email: elton.ngan@ubc.ca

Short Biography

Dr. Ngan graduated from McGill University Faculty of Medicine in 1986. He completed his residency in Psychiatry in 1995 and joined the academic Faculty of the Department of Psychiatry at The University of British Columbia in 1996.

Research Focus

Dr. Ngan’s primary research  focused is in cognition in schizophrenia using functional imaging modalities, including Functional Magnetic Resonance Imaging, Positron Emission Tomography and Event Related Potentials.

Clinical Focus

Site Co-ordinator for the  chronic care rotation for psychiatry residents at Lions Gate Hospital

Timothy H. Murphy

Timothy H. Murphy

Professor, UBC Department of Psychiatry, Division of Neuroscience and Translational Psychiatry

Division Head, Neuroscience and Translational Psychiatry, UBC Department of Psychiatry

Member, Djavad Mowafaghian Centre for Brain Health

Email: timothy.murphy@ubc.ca

Short Biography

Dr. Tim Murphy is a foundational scientist who studies how the mouse cortex adapts after stroke by remapping of brain function from damaged to surviving areas. The Murphy Lab develops new imaging and optogenetic methods that have parallels to human brain imaging and stimulation tools. He leads UBC’s Dynamic Brain Circuits in Health and Disease Cluster and participates in the Canadian Neurophotonics Platform.

Research Focus

Dr. Murphy uses high-resolution imaging of individual synapses and sensorimotor circuits in live mice to provide insight into mechanisms of initial stroke damage and stroke recovery. The lab has developed models of neurological and psychiatric diseases through internet-enabled mouse homecages used to manipulate and assess brain activity. More recent work has focused on developing a synthetic human form as a means of quantifying changes in neurological disease.

Significant Accomplishments & Professional Contribution

2010 UBC Killam Research Prize Science, Applied Science, Medicine Category

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