Tamara Vanderwal

Tamara Vanderwal

Tamara Vanderwal

Assistant Professor, UBC Department of Psychiatry, Division of Child and Adolescent Psychiatry

Child Psychiatrist, Telehealth Outreach Psychiatric Services (TOPs) Program, BC Children’s Hospital

Investigator, BC Children’s Hospital Research Institute

Email: tamara.vanderwal@ubc.ca

Short Biography

Dr. Vanderwal received her M.D. from Yale School of Medicine, and completed residency, fellowship and research training at the Yale Child Study Center. Her research mentors were Robert T. Schultz, Linda C. Mayes and F. Xavier Castellanos (and team). She also has a Master’s degree from Yale Divinity School, with a concentration in ethics. Dr. Vanderwal’s work combining neuroscience and art has been featured at the Imagine Science Film Festival and at MoMA Studios. She is currently the managing guest editor for the special issue/saga on Naturalistic Imaging for NeuroImage. She also continues to practice as a child psychiatrist, seeing kids in northern BC.

Source

Research Focus

The Naturalistic Neuroimaging Lab uses movies to study complex patterns of brain function in child psychiatric disorders. Using movies helps us study children who have a hard time staying still inside the MRI machine. The movies also enable us to study the brain as it processes complex, dynamic streams of information like it does in real life. This approach is similar to having a patient run on a treadmill while studying that person’s heart function. We design and test movies to evoke specific symptoms or types of cognitive processes, and are developing novel analyses to leverage the unique kind of data we acquire using movies in functional MRI.

Publications

Peer-reviewed publications

Contributing Editor (2014-2017), The Journal of the American Academy of Child and Adolescent Psychiatry

Significant Accomplishments & Professional Contribution

  • American Academy of Child and Adolescent Psychiatry Junior Investigator Award
  • Resident Teaching Award, Department of Psychiatry, Yale School of Medicine
  • Yale Psychiatry Research Scholar, Yale School of Medicine

Steven Taylor

Steven Taylor

Professor, UBC Department of Psychiatry, Division of Neuroscience and Translational Psychiatry

Researcher, Vancouver Coastal Health Research Institute

Email: steven.taylor@ubc.ca

Short Biography

Steven Taylor, is a Professor and Clinical Psychologist in the Department of Psychiatry. Dr. Taylor’s work focuses on anxiety disorders and related clinical conditions, and on the psychology of pandemics. Dr. Taylor is a member of the Canadian federal government’s expert panel on COVID-19, and a co-leader of the Psychology of Pandemics Network.

Research Focus

Anxiety disorders: Classification, biopsychosocial etiology, and treatment

Publications

View publications

Dr. Taylor has authored 20 books and most recently “ The Psychology of Pandemics: Preparing for the Next Global Outbreak of Infectious Disease”, Cambridge Scholars Publishing, 2019

Significant Accomplishments and Professional Contribution

2005 Scientist-Practitioner Award, British Columbia Psychological Association

2010 Self-Help Book of Merit Award, Association for Behavioral and Cognitive Therapies

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S. Evelyn Stewart

S. Evelyn Stewart

Professor, UBC Department of Psychiatry, Division of Neuroscience and Translational Psychiatry / Division of Child and Adolescent Psychiatry

Congdon Family Hospital Chair in Child and Youth Mental Health Research, BC Children’s Hospital

Medical Director, BCCH Provincial OCD Program (POP)

Director, Brain, Behavior & Development Research Theme and Investigator, BC Children’s Research Institute

Director of Research, Child and Adolescent Psychiatry, BC Children’s Hospital

Researcher, BC Mental Health and Substance Use Services Research Institute

Email: evelyn.stewart@ubc.ca

Short Biography

Dr. Evelyn Stewart is a tenured, academic-track Professor in the Department of Psychiatry, University of British Columbia and is the founding director of the Pediatric Obsessive-Compulsive Disorder Clinic and Research Program as well as the Chair of the Child and Youth Mental Health Research at BC Children and Women’s Health Centre. She is a clinical, genetic and neuroscience researcher, as well as a child and adolescent psychiatrist.

Her research focuses on biologic, phenotypic, familial, and treatment aspects of childhood-onset neuropsychiatric disorders, such as obsessive-compulsive disorder (OCD). Dr. Stewart has authored over 150 original papers, reviews, and chapters on genetic, clinical, and treatment aspects of OCD, Tourette’s Disorder, and related illnesses. She sits on the Scientific and Clinical Advisory Board of the International OCD Foundation and is the vice chair of the Research and Scientific Program Committee for Canadian Academic of Child and Adolescent Psychiatry.

At BCCHR, her leadership contributions include being Research Director of the BCCH Mental Health program, the BCCH Mindfulness Centre and the BCCH Research Institute’s Brain, Behaviour and Development theme.

Source

Research Focus

Adjunctive Celecoxib in childhood-onset OCD (ACEOCD) study: The goal of this study is to determine the effects of the anti-inflammatory medication celecoxib – when added to participants’ usual treatment(s) – on OCD symptoms over 12 weeks. Celecoxib belongs to a medication class called non-steroidal anti-inflammatory drugs (NSAIDS). A common NSAID that many children have taken previously is ibuprofen, but it requires several doses per day to effectively reduce inflammation whereas celecoxib is taken only twice daily. NSAIDs may improve the function of parts of the brain involved in OCD symptoms.

Genetic Architecture of Youth Anxiety Study (GAYA): Anxiety disorders can significantly interfere with youth’s lives, so it is important to better understand how and why these disorders develop through mechanisms like genetics. To better understand the development of anxiety disorders among youth, we need to include larger samples of youth in current genetic research. The GAYA study represents a Pan-Canadian effort of clinical and genetic experts with recruitment sites in Vancouver, Calgary, Hamilton, Toronto, and Halifax. The study is funded by the Canadian Institute of Health Research.

Personal Impacts of COVID-19 Survey (PICS): In light of the COVID-19 pandemic, our team is interested in learning about the personal impacts it has made on families and individuals. We have created a survey to capture information about the effect COVID-19 has had on individuals’ thoughts, feelings and actions, along with their coping mechanisms and any resources available to them.

As PI:

  • Adjunctive Celecoxib in childhood-onset OCD (ACEOCD)
  • Personal Impacts of COVID-19 in child and adolescents
  • Biomarkers of stress and inflammation in youth with OCD and their parents participating in Group-based Family Cognitive-Behaviour Therapy
  • Obsessive-Compulsive Disorder (OCD) Registry and DNA Repository
    Clinical Outcomes following Group-based Family Cognitive-Behaviour Therapy in Pediatric Obsessive- Compulsive Disorder (OCD).
  • Mindfulness Training versus Peer Support Groups for Parents of Obsessive-Compulsive Disorder
  • Youth OCD Diagnosis Disclosure

As Co-Investigator:

  • Genetic Architecture of Youth Anxiety Study
  • OCD genomics

Publications

Significant Accomplishments & Professional Contribution

  • 2023 Awarded 2023 Faculty of Medicine Distinguished Achievement Award for Excellence in Service to the University and Community, University of British Columbia
  • 2023 Nominated for Canadian Academy of Health Sciences (CAHS) fellowship.
  • 2022 Nominated for YWCA Women of Distinction Award Program, YWCA Metro Vancouver
  • 2022 Awarded Top Cited Article for, “An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration,”
  • Wiley Publication, USA
  • 2021 Awarded BC Children’s Hospital Research Institute Geoffrey L. Hammond Lectureship, BC Hospital Research Institute
  • 2021 Awarded Genius Bar Award, Journal of the American Academy of Child & Adolescent Psychiatry
  • 2018 UBC Faculty of Medicine Distinguished Achievement Award for Excellence in Clinical or Applied Research
  • 2017 Norbert and Charlotte Rieger Award for Scientific Achievement American Academy of Child and Adolescent Psychiatry

Terrance Snutch

Terrance Snutch

Professor, UBC Department of Psychiatry, Division of Neuroscience and Translational Psychiatry, UBC Department of Zoology and UBC Michael Smith Laboratories

Canada Research Chair, Biotechnology and Genomics-Neurobiology

Director, Translational Neuroscience, Djavad Mowafaghian Centre for Brain Health

Email: snutch@msl.ubc.ca

Short Biography

Dr Terrance Snutch completed his PhD in molecular genetics at Simon Fraser University and then work as a post-doctoral fellow at CalTech. He joined UBC about three decades ago and is based at the Michael Smith Laboratories. He is Canada Research Chair in  Biotechnology and Genomics-Neurobiology and Director, Translational Neuroscience, Djavad Mowafaghian Centre for Brain Health. The Snutch Lab employs state-of-the-art 3rd generation sequencing (MinION) aimed at defining genetic and epigenetic disease-related states, with emphasis on the discovery of new drugs for epilepsy and chronic pain.

Research Focus

The Snutch Lab research facilities are located in the Michael Smith Laboratories and the Djavad Mowafaghian Centre for Brain Health, on the campus of The University of British Columbia in beautiful Vancouver, BC, Canada.

Under the direction of Professor Terrance P. Snutch, the lab’s major research interest is the study of the molecular mechanisms of signal transduction in the nervous system and its relationship to neurological disorders. The research utilizes a multidisciplinary approach to characterize various aspects of the molecular, electrophysiological, pharmacological, biochemical and genetic properties of ion channels in normal and pathophysiological states.

Current projects involve epilepsy, migraine, schizophrenia, autism and chronic pain. The lab also employs state-of-the-art 3rd generation sequencing (MinION) aimed at defining genetic and epigenetic disease-related states. Prof. Snutch actively translates discoveries to industry and patients and to date, has designed and advanced new drugs for pain and epilepsy into the clinic.

Significant Accomplishments and Professional Contribution

2021 Faculty of Medicine Bill and Marilyn Webber Lifetime Achievement Award

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Christian Schütz

Christian Schütz

Professor (Partner), UBC Department of Psychiatry, Division of Substance Use & Concurrent Disorders

Head, Division of Substance Use & Concurrent Disorders, UBC Department of Psychiatry

Clinician Scientist, Djavad Mowafaghian Centre for Brain Health

Research, Education and Evaluation Medical Manager, Red Fish Healing Centre for Mental Health and Addiction

Director, Research, Adult Mental Health and Substance Use, BC Mental Health & Substance Use Services, PHSA

Scientist, UBC Centre for Health Evaluation & Outcome Sciences (CHEOS)

Researcher, Vancouver Coastal Health Research Institute

Member, UBC Institute of Mental Health

Email: christian.schutz@ubc.ca

Short Biography

Academic background: MD from Albert-Ludwigs-University, Freiburg, Germany, PhD from Ludwig-Maximilians-University, Munich, Germany and MPH from Johns-Hopkins -University, Baltimore MD. Fellowship at NIDA/NIH, Baltimore MD (Behavioral Pharmacology), sabbatical at Yale University, New Haven, CT (Clinical Neuroscience).

Clinical background: Medical specialist in Psychiatry, Psychotherapy, and Addiction Medicine. Training in Public Health.

Research Focus

Dr. Schütz’s main research interests focus on the clinical interventions and health service in substance use disorders and dual diagnoses (mental plus substance use disorders), as well as neurobiological and neurocognitive aspects of impulsive decision-making.

His focus is on understanding the mechanism of relapse and impulsive decision-making to improve treatment of addiction and concurrent disorders; developing novel interventions focused on stimulant use disorders; and developing a more comprehensive integrated min/brain-based sound concept of motivation and decision-making. Publications include over 170 research articles.

He has spoken in over 250 presentations across Europe and North America, discussing the latest scientific findings about substance use disorders and concurrent disorders.

Dr. Schütz is also the Principal Investigator of the B.R.A.I.N. Lab.

Source: https://brainlab.med.ubc.ca/people/

Significant Accomplishments and Professional Contribution

  • 2020 Outstanding Academic Performance (OAP), Faculty of Medicine, University of British Columbia
  • 2019 Outstanding Academic Performance (OAP), Faculty of Medicine, University of British Columbia
  • 2018 Outstanding Academic Performance (OAP), Faculty of Medicine, University of British Columbia
  • 2017 NARSAD Independent Investigator Award, Brain and Behaviour Foundation
  • 2015 – present Founding Member, World Association of Dual Diagnosis (WADD)
  • 2013 – present Member, Canadian Psychiatric Association (Chair Addiction Psychiatry Section)
  • 2012 – present Member, World Psychiatric Association, Section on Addiction Psychiatry
  • 2012 – present Member, College International for Neuropsychiatry (CINP)
  • 2012 – present Member, International Society for Research on Impulsivity (ISIR)
  • 2021 – Present Member, BC Ministry of Mental Health & Addiction Core Advisory Group for MHA Research 
  • 2020 – present Member, Psychedelic Medicine Assisted Therapy Advisory Committee organized by BC Ministry of Mental Health & Addiction
  • 2019 – present Member, Provincial Concurrent Disorder Technical Panel
  • 2019 – present Advisory Committee Member, Planning for the Appropriate Use of Prescription Heroin, Addictions and Mental Health Ontario
  • 2013 – 2019 Chair, Addiction Psychiatry Section, Canadian Society of Psychiatry

Jeremy Seamans

Jeremy Seamans

Professor, UBC Department of Psychiatry, Division of Neuroscience and Translational Psychiatry

Member, Djavad Mowafaghian Centre for Brain Health

Email: jeremy.seamans@ubc.ca

Short Biography

Dr. Jeremy Seamans is Professor of Psychiatry. His lab uses powerful optically-based tools (e.g. optogenetics and fluorescence imaging) to examine the function of the Anterior Cingulate Cortex (ACC), and its modulation by neurotransmitters, using recordings from animals performing cognitive or emotional tasks.

Research Focus

Dr. Seamans’ main research interest lies in a part of the brain known as the Anterior Cingulate Cortex (ACC). There is no consensus on what the ACC actually does, although there are no shortage of theories. On one hand, functional imaging has shown that the ACC is “activated” during a staggering array of cognitive and emotional tasks. On the other hand, when the ACC is surgically removed (anterior cingulotomies) in human patients for the treatment of severe cases of obsessive compulsive disorder, chronic pain or depression, no lasting detrimental effects on cognition, memory or emotional expression occur.

Dr. Seamans’ lab takes a reductionistic approach to understanding this mysterious brain region. This involves simultaneously recording from many ACC neurons as animals perform various cognitive or emotional tasks. They then apply sophisticated statistical and machine learning techniques to extract meaningful signals from the jumble of activity. Typically, the team finds that ACC neurons can represent almost anything (e.g. stimuli, actions, outcomes and emotional states) but perhaps more interesting is that these representations morph or change with changes in context. Because we believe the morphing relies on neuromodulators such as dopamine and serotonin, Dr. Seamans uses powerful optically-based tools (e.g. optogenetics and fluorescence imaging) to tract fluctuations in these modulators.

By studying how ACC neurons represent cognitive and emotional information and what causes these representations to change, Dr. Seamans’ lab hopes to better understand what the ACC normally does, and how dysfunction of the ACC might contribute to severe psychiatric disorders.

Significant Accomplishments & Professional Contribution

2015 UBC Faculty of Medicine Distinguished Achievement Award – Excellence in Basic Science Research

Peter B. Reiner

Peter B. Reiner

Professor Emeritus, UBC Department of Psychiatry

Lynn Raymond

Lynn Raymond

Professor & Louise A. Brown Chair in Neuroscience, UBC Department of Psychiatry, Division of Neuroscience and Translational Psychiatry

Co-Director, Djavad Mowafaghian Centre for Brain Health

Director, Huntington Disease Medical Clinic

Researcher, Vancouver Coastal Health Research Institute

Associate Member, Division of Neurology (Medicine) & Department of Cellular and Physiological Sciences

Email: lynn.raymond@ubc.ca

Short Biography

Dr. Lynn Raymond is the Director of the Djavad Mowafaghian Centre for Brain Health. She is also a Professor in the Department of Psychiatry, the Louise A. Brown Chair in Neuroscience and Clinic Director of the Centre for Huntington Disease.

Dr. Raymond is an internationally renowned neuroscientist and neurologist, and her work bridges foundational science and clinical research. She has more than 170 publications, and her work has been cited more than 11,000 times. She has devoted her career to better understanding the specific roles of altered neuronal circuits and amino acid neurotransmitter receptors in Huntington disease, with the aim of developing disease-modifying therapy. Her work is funded by the Canadian Institutes of Health Research, the John Evans Leadership Fund, and she has held funding from a variety of not-for-profit organizations including the Cure Huntington’s Disease Initiative and Huntington Society of Canada.

Research Focus

Dr. Lynn Raymond combines neuroscience research with clinical practice in Neurology. Her lab investigates pathogenic mechanisms of Huntington disease (HD), as well as glutamate receptor structure-function, modulation and signaling. Working with HD mouse models, Dr. Raymond made significant contributions to focusing the field on altered striatal neuronal NMDA-type glutamate receptor (NMDAR) trafficking and excitatory synaptic signaling as central mechanisms of early striatal dysfunction. More recently, her lab has focused on early changes in cortical-striatal and cortical pyramidal glutamatergic synaptic plasticity, which may contribute to impairments in learning and cognitive flexibility, as well as promote selective neuronal degeneration. The lab also developed an automated home-cage system for assessing motor learning, and uses electrophysiological and optogenetic approaches to study cortical and striatal activity in awake behaving mice in vivo to determine circuit changes underlying HD. Dr. Raymond served as President for the Canadian Association for Neuroscience. As Site PI of several clinical trials and observational studies, she contributes data to publications on multi-centre studies in HD

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Anthony Phillips

Anthony Phillips

Professor, UBC Department of Psychiatry, Division of Neuroscience and Translational Psychiatry

Scientific Director, Mental Health and Addiction, CIHR Institute of Neurosciences

Founding Director, UBC Institute of Mental Health

Senior Scientist, UBC/VCH Brain Research Centre

Member, Djavad Mowafaghian Centre for Brain Health

Researcher, Vancouver Coastal Health Research Institute

Email: anthony.phillips@ubc.ca

Short Biography

Dr. Anthony Phillips received his PhD in Psychology from the University of Western Ontario, under the mentorship of Gordon Mogenson and subsequently spent time in the laboratories of Elliot Valenstein and James Olds at the Fels Research Institute and Division of Biology at the California Institute of Technology, respectively.

He joined the Department of Psychology at the University of British Columbia in 1970, was appointed full professor in 1980. He then served as head of the department from 1994-99. He subsequently joined the Department of Psychiatry, Faculty of Medicine, UBC in 2000 and became the Founding Director of the UBC Institute of Mental Health in 2005. Dr. Phillips served for two terms (2001-07) as the inaugural Chair of the Advisory Board for the CIHR Institute of Neurosciences, Mental Health and Addiction.
Dr. Phillips also played an important role in the evolution of the biotechnology industry in Canada, having been a Founding Director of QLT and serving as Secretary/Treasurer to its Board from 1982-92, and currently as a Founder and Member of the Board of Allon Therapeutics Inc. He has been elected as President (2012-14) of the Collegium Internationale Neuro-Psychopharmacologicum (CINP).

Research Focus

Dr. Phillips’ research interests are broadly based within the field of pre-clinical neuropsychopharmacology and systems neuroscience. He has published over 300 peer- reviewed articles and book chapters. His pioneering research, with H.C. Fibiger, laid the foundation for the role of dopamine in the neural control of motivation and memory, with its clinical implications for understanding biological correlates of addiction. He has a long-standing interest in applying knowledge concerning normal brain-behavior function to understanding the neural bases of mental illness and addiction.

Significant Accomplishments & Professional Contribution

Dr. Phillips’ distinguished awards include: Canada Council Killam Senior Research Scholar (1978-80) and E.W.R. Steacie Fellow, NSERC (1980-82). In 1986, he was elected a Fellow of the Royal Society of Canada and was also the recipient of an inaugural UBC Killam Research Prize. The Canadian Psychological Association honoured him in 1995 with the Donald O. Hebb Award for `Distinguished Contributions to Psychology as a Science.’ In 1996, the Canadian College of Neuropsychopharmacology awarded him with the inaugural prize for `Innovations in Neuropsychopharmacoloty’ (with H.C. Fibiger) and in 2009, with the Heinz Lehmann Award. In 2010, Dr. Phillips was elected a Fellow in the Canadian Academy of Health Sciences.

Paul Pavlidis

Paul Pavlidis

Professor, UBC Department of Psychiatry, Division of Neuroscience and Translational Psychiatry

Associate Director, UBC Graduate Program in Bioinformatics

Member, Djavad Mowafaghian Centre for Brain Health

Email: paul@msl.ubc.ca

Short Biography

Dr. Paul Pavlidis is a Professor of Psychiatry based at the Michael Smith Laboratories. He obtained his B.A. in Biochemistry from Cornell University (1989) and his doctorate in Molecular Biology/Neursocence from the University of California, Berkeley (1994). He completed post-doctoral fellowships at Stanford University and Columbia University prior to his appointment as Assistant Professor at Columbia University in 2003. He moved to UBC in 2006 and was promoted to full professor in 2014. His lab focuses on research that is at the intersection of bioinformatics and neuroscience, with a focus on genomics.

Research Focus

Dr. Pavlidis’ research lies at the intersection of bioinformatics and neuroscience. Dr. Pavlidis has a particular interest in neuropsychiatric disorders such as schizophrenia and autism, and how they affect the function of chemical synapses. A current focus of work in his lab involves the large-scale or meta-analysis of functional genomics data (e.g. microarrays). He uses these approaches to study gene networks and their involvement in human neuropsychiatric diseases. To this end Dr. Pavlidis collaborates closely with many laboratory-based neuroscience researchers from UBC and elsewhere. A newer area of interest is in the analysis of neuroanatomical data. Using text mining as well as existing data sources, he is engaged in the analysis of brain structure as it relates to gene expression and the brain “connectome”. As computational biologists, they also generate methods, databases and tools. One of the tools they have developed, “Gemma” is a system that permits researchers to compare and combine gene expression data sets they have generated with other data sets they select from hundreds of other data sets. Gemma will also facilitate the use of other types of data including and proteomics and genetics, and neuroscience-domain-specific data such as neuroanatomy and neuropharmacology.

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